Preventive cardiologyHigh-Density Lipoprotein Cholesterol Efflux, Nitration of Apolipoprotein A-I, and Endothelial Function in Obese Women
Section snippets
Methods
The present study was conducted at the Clinical Center of the National Institutes of Health with employees enrolled in a worksite wellness program initiated by the National Heart, Lung, and Blood Institute. The protocol, approved by the institutional review board of the National Heart, Lung, and Blood Institute (NCT00666172), was open to women according to the body mass index (BMI; weight in kilograms divided by height in meters squared) classification of overweight (25 to 29.9 kg/m2) or obese
Results
A total of 54 consecutive women meeting the eligibility criteria (age range 26 to 66 years) were enrolled during the initial year of the protocol and were evaluated in the present study. Of the 54 women, 20 were identified as overweight (BMI 25 to 29.9 kg/m2) and 34 as obese (BMI ≥30 kg/m2; Table 1). Of the 54 women, 7 (6 with a BMI of ≥30 kg/m2 and 1 with a BMI of 25 to 29.9 kg/m2) had adult-onset diabetes. Of these 7, 6 were taking oral hypoglycemic medications and 1 required insulin. For the
Discussion
In our cohort of overweight (BMI 25 to 29.9 kg/m2) and obese (BMI ≥30 kg/m2) women, we found that HDL cholesterol levels were inversely associated with obesity, consistent with previous reports from large cohorts of men and women.13, 14, 15 The range of HDL cholesterol levels was wide, and 17 women (including 6 of 34 subjects with a BMI of ≥30 kg/m2) had values ≥60 mg/dl, well within the desirable range by current Adult Treatment Panel III guidelines.16 Using a cell-based assay to quantify the
Acknowledgments
We gratefully acknowledge the technical contributions of Maureen Sampson and John Stonik to our study.
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This research was funded by the intramural research programs of the National Heart, Lung, and Blood Institute and the Clinical Center, National Institutes of Health, Bethesda, Maryland.
Dr. Vazquez (Mt. Sinai School of Medicine) was a fellow in the Clinical Research Training Program, Clinical Center, National Institutes of Health, Bethesda, Maryland; his current address is New York Presbyterian Hospital, New York, New York.