The American Society of Breast SurgeonsRapid noninvasive optical imaging of tissue composition in breast tumor margins
Section snippets
Patients
The study was approved by the institutional review board at Duke University in accordance with assurances filed with and approved by the Department of Health and Human Services. Informed consent was obtained from eligible participants (women >18 y) undergoing primary BCT for an invasive or noninvasive breast malignancy. A subgroup recruited to this study had undergone neoadjuvant endocrine or chemotherapy before their surgical procedure. Surgeries were performed by 5 breast surgical oncologists
Results
From December 2007 to September 2008, 54 patients were enrolled in this study. Optical spectral imaging data from 6 patients were not used in this analysis because the pathologic outcomes could not be coregistered accurately with the specified margins. From the remaining 48 patients, 55 margins were evaluated with the optical spectral imaging device. Table 1 contains a summary of the patient and margin characteristics for the participants in this study. Twenty-one patients had negative margins,
Comments
Most women with early stage breast cancer can undergo BCT. As the number of women who are treated neoadjuvantly with endocrine or chemotherapy increases, the eligible population for BCT will continue to grow. Recognizing, however, that anywhere from 16% to 60% of patients with BCT require a second surgery, a rapid, noninvasive, readily available technology is necessary to reduce this inability to detect tumor at the edge of a breast specimen in the operating room.11, 12, 13, 14, 15 This study
Acknowledgments
This publication was made possible by grant number 1UL1 RR024128-01 from the National Center for Research Resources, a component of the National Institutes of Health, and National Institutes of Health Roadmap for Medical Research. Its contents are solely the responsibility of the authors and do not necessarily represent the official view of the National Center for Research Resources or National Institutes of Health.
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