Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Volume 1783, Issue 2, February 2008, Pages 297-311
S100A8/9 induces cell death via a novel, RAGE-independent pathway that involves selective release of Smac/DIABLO and Omi/HtrA2
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Abbreviations
ΔΨm
mitochondrial membrane potential
AIF
apoptosis-inducing factor
BH3
Bcl2 homology 3
BNIP3
Bcl2/adenovirus E1B 19 kD-interacting protein 3
DD
death domain
DED
death effector domain
DISC
death inducing signaling complex
Drp
dynamin-related protein
DTPA
diethylene triamine pentaacetate
Endo G
endonuclease G
FADD
Fas-Associated Death Domain
FADD-DN
dominant-negative FADD mutant
HtrA2
high-temperature requirement A2
IAPs
inhibitors of apoptosis
IM
inner membrane
JC-1
5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolylcarbocyanine iodide
MTT
3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide
RAGE
receptor for advanced glycation endproducts
ROS
reactive oxygen species
Smac/DIABLO
second mitochondrial activator of caspases/direct inhibitor of apoptosis binding protein of low PI
XIAP
X-linked inhibitor of apoptosis
Keywords
Bcl2 protein family
S100/calgranulin
Cancer regression
Drp1
Receptor for advanced glycated endproducts (RAGE)
Mitochondrial fission
XIAP
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