Review
Driving ribosome assembly

https://doi.org/10.1016/j.bbamcr.2009.10.009Get rights and content
Under an Elsevier user license
open archive

Abstract

Ribosome biogenesis is a fundamental process that provides cells with the molecular factories for cellular protein production. Accordingly, its misregulation lies at the heart of several hereditary diseases (e.g., Diamond-Blackfan anemia). The process of ribosome assembly comprises the processing and folding of the pre-rRNA and its concomitant assembly with the ribosomal proteins. Eukaryotic ribosome biogenesis relies on a large number (>  200) of non-ribosomal factors, which confer directionality and accuracy to this process. Many of these non-ribosomal factors fall into different families of energy-consuming enzymes, notably including ATP-dependent RNA helicases, AAA-ATPases, GTPases, and kinases. Ribosome biogenesis is highly conserved within eukaryotic organisms; however, due to the combination of powerful genetic and biochemical methods, it is best studied in the yeast Saccharomyces cerevisiae. This review summarizes our current knowledge on eukaryotic ribosome assembly, with particular focus on the molecular role of the involved energy-consuming enzymes.

Keywords

Ribosome assembly
Nuclear export of ribosomes
Diamond-Blackfan anemia
Shwachman-Diamond syndrome
Dyskeratosis congenita
Cartilage–hair hypoplasia
Bowen-Conradi syndrome
Cancer
Quality control of ribosomes

Cited by (0)