Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Volume 1813, Issue 1, January 2011, Pages 27-38
Nucleolar localization/retention signal is responsible for transient accumulation of histone H2B in the nucleolus through electrostatic interactions
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Research Highlights
►Histone H2B-GFP initially accumulated in the nucleolus after ectopic expression. ►The region that acts as a nucleolar retention signal (NoRS) was identified. ►This signal overlapped with a nuclear localization signal (NLS). ►The interaction of histone H2B with the nucleolus was non-specific. ►NoRSs appear to achieve their function through simple electrostatic interactions.
Keywords
Nucleolus
Histone H2B
Nucleolar localization/retention signal
Electrostatic interaction
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