Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Volume 1823, Issue 1, January 2012, Pages 40-48
ReviewStructure and function of the bacterial AAA protease FtsH☆
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Highlights
► FtsH is a conserved AAA protease found in eubacteria, mitochondria and chloroplasts. ► As typical for AAA+ proteases, bacterial FtsH forms barrel-shaped homo-hexamers. ► FtsH is membrane-anchored and crucial for membrane protein quality control. ► In E. coli, FtsH is essential due to regulation of lipopolysaccharide biosynthesis. ► FtsH plays a role in regulation of the E. coli heat shock response.
Abbreviations
TM
transmembrane domain
HS
heat shock
LPS
lipopolysaccharides
PL
phospholipids
PS
photosystem
Keywords
FtsH
Proteolysis
AAA protein
LpxC
LPS biosynthesis
Heat shock
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This article is part of a Special Issue entitled: AAA ATPases: structure and function.
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