Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Volume 1823, Issue 1, January 2012, Pages 117-124
ReviewThe Cdc48 machine in endoplasmic reticulum associated protein degradation☆
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Highlights
►Cdc48 is a type II AAA-type ATPase with two ATP binding domains. ►From the many cellular functions of Cdc48 its involvement in ERAD is understood best. ►Cdc48 function is driven by several substrate recruiting and substrate processing co-factors. ►Cdc48 is a molecular motor with ratcheting and segregase activity.
Keywords
AAA-type ATPase
Cdc48
p97/VCP
Cdc48–Ufd1–Npl4 complex
ER-associated protein degradation (ERAD)
Ubiquitin–proteasome-system (UPS)
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This article is part of a Special Issue entitled: AAA ATPases: Structure and function.
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