Short communicationOne week of exposure to intermittent hypoxia impairs attentional set-shifting in rats
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Acknowledgements
This research was supported by the Department of Veteran's Affairs (RES and RWM), NIH HL060292 (RWM and RES), NIH T32 HL07901 (JTM) and NIH F32 MH070156 (JTM).
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2014, Pathologie BiologieCitation Excerpt :The heterogeneity found in the literature for the association between hypoxemia and cognitive functioning is possibly due to the role of non-controlled variables, such as age or premorbid intellectual functioning. Animal models have shown that intermittent hypoxemia was associated with impairments in the execution component of attention (i.e. set-shifting) and to a particular vulnerability to neuronal loss in the frontal lobe [67,68]. Several studies investigated the association between the severity of OSA as measured with AIH and the cognitive deficits found in this population.
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2013, American Journal of MedicineCitation Excerpt :Immobility and lack of physical therapy in patients hospitalized for pneumonia could exacerbate age-related muscle atrophy33 and may worsen direct inflammatory, apoptotic, and hypoperfusion-mediated muscle fiber and neuronal degradation.7,34,35 Pneumonia-related hypoxia may contribute to subsequent cognitive impairment.36,37 Also, proinflammatory cytokines are elevated in patients with pneumonia and in depressed patients,38,39 and have been hypothesized to lead to late-life neurodegenerative changes.40
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2011, Neurobiology of Learning and MemoryCitation Excerpt :Rodent models of the chronic intermittent hypoxia that patients experience in obstructive sleep apnea indicate that oxidative stress and subsequent cortical neuronal apoptosis may mediate the chronic intermittent hypoxia-induced behavioral impairments observed (Gozal, Daniel, & Dohanich, 2001; Xu et al., 2004). Hence, the next study described examined the effect of 7 d of intermittent hypoxia on attentional set-shifting (McCoy et al., 2010). Interestingly, sub-chronic (10 h/day for 7 days) treatment of rats with intermittent hypoxia resulted in an impairment on the attentional set-shifting task (namely, a selective deficit on the extradimensional shift) that was similar to that observed following the acute (i.e., 24 h) exposure to SF (McCoy et al., 2007).