Priority communicationA Reversal of the Normal Pattern of Parahippocampal Response to Neutral and Fearful Faces Is Associated with Reality Distortion in Schizophrenia
Section snippets
Participants
Fifteen male individuals with a DSM-IV diagnosis of schizophrenia were recruited from outpatient clinics of the South London and Maudsley Trust, United Kingdom. The diagnosis of schizophrenia was made by psychiatrists using the Structured Clinical Interview for DSM-IV (SCID) (First et al 1995). Eleven healthy male control individuals matched for age and years of education were recruited from ancillary staff at the Maudsley Hospital and the local population. Exclusion criteria for all
Results
The 3 × 2 ANOVA of the whole brain statistical data produced a difference map [interaction intensity by group; F(1.4,34.3) = 3.8; p < .05] comprising one cluster centered within the right parahippocampal gyrus, which extended into the right hippocampus (coordinates: x = 18/22, y = −18/−22, z = −18/−23). There were no other main effects or interactions. The significant interaction was driven by the greater BOLD response in the right parahippocampal gyrus to neutral faces in individuals with
Discussion
We aimed to examine neural responses to fearful and neutral facial expressions in individuals with schizophrenia and the relationship between specific symptom dimensions and patterns of neural response to these stimuli in this population. Our findings demonstrate for the first time that individuals with schizophrenia can be distinguished from healthy control subjects by their differential patterns of neural response to fearful and neutral faces. While individuals with schizophrenia demonstrated
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2016, Journal of Affective DisordersCitation Excerpt :More importantly, statistical analyses revealed that in the sad block, the group difference of the P3 was due to impaired processes for subliminally presented neutral (but not sad) faces in the patients (reflected by reduced P3 for neutral faces). Although we cannot find appropriate literatures in depressed population to support this finding, many emotional studies in schizophrenia have indicated abnormal neural responses to neutral stimuli (Hall et al., 2008; Holt et al., 2011; Surguladze et al., 2006). One possible explanation for the reduced P3 in the neutral trials may be that in the sad block, the patients tended to avoid elaborately processing of neutral faces so they could keep enough cognitive resources available for mood-congruent sad stimuli.