Archival ReportThe FKBP5-Gene in Depression and Treatment Response—an Association Study in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) Cohort
Section snippets
Patients and Study Design
This study presents data obtained from level 1 of the STAR*D study, whose overall study design has been described elsewhere (17, 18, 19). Diagnoses were established according to DSM-IV criteria, and only non-psychotic MDD was included. A diagnosis of bipolar disorder led to exclusion from the study.
The treatment regime at level 1 aimed to evaluate outcome of treatment with the antidepressant drug citalopram (18, 20). To reduce the risk of inadequate dosing and to ensure that patients who
Case-Control Study
In the comparison of cases and control subjects, nominally significant associations of markers rs1360780 and rs4713916 with disease were identified in the White non-Hispanic population in a genotype-wise test (Table 1). However, only the finding in rs1360780 remained significant after correction for multiple testing (p = .046). The CC-genotype was more frequent in control subjects than in cases (50% vs. 44%), whereas the TC-heterozygote genotype was over-represented in cases (46% vs. 38%). No
Case-Control Study
Sufficient power to detect association of genotype to phenotype can only be obtained with large sample sizes (29), especially when genes that only partially contribute to the disease susceptibility shall be identified. Furthermore, association signals must be strong enough to survive correction for multiple testing, as carried out in this study as well as in the original FKBP5-study.
The present case-control analysis was carried out including 1256 White non-Hispanic individuals matched with 634
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