Archival ReportDifferential Effects of High-Dose Magnetic Seizure Therapy and Electroconvulsive Shock on Cognitive Function
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Subjects
This study was approved by the Institutional Animal Care and Use Committee (IACUC) of the New York State Psychiatric Institute and Columbia University. The subjects were three pathogen-free male rhesus macaca mulatta monkeys obtained from the same National Institutes of Health (NIH) breeding colony. Mean age upon entering the study was 83 (± 26) months, mean weight was 8 (± 1) kg, and all three were past sexual maturity. The approximate age equivalent in human years was 20.8 (± 6.5) years (22,
Feasibility of High-Dose MST Seizure Induction
The MST seizure was induced in all three subjects, and there were no adverse events. The observed MST seizure thresholds were 225 pulses for subject 1, 100 pulses for subject 2, and 300 pulses for subject 3. In the MST condition, there was a mean seizure duration of 24.2 ± 5.3 (SD) sec. This was significantly longer [F(48) = .51, p = .015] than MST seizure duration in the moderate-dose study, where the mean seizure was 19.8 ± 7.4 (SD) sec. However, there was no significant difference between
Discussion
We have shown for the first time that chronic treatment with high-dose MST resulted in less cognitive impairment than ECS (see Table 1 for summary) and that high-dose MST did not significantly differ from the effects of anesthesia alone. Moreover, increasing MST dosage from 2.5 × seizure threshold to 6 × seizure threshold did not impair cognitive performance on most measures. These results support the feasibility and safety of high-dose MST for subsequent work in humans to assess its efficacy
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