Research ReportFunctional and Structural Connectivity Between the Perigenual Anterior Cingulate and Amygdala in Bipolar Disorder
Section snippets
Subjects
The Structured Clinical Interview for DSM-IV Axis I Disorders Version 2.0 (27) confirmed the presence or absence of Axis I Disorders and mood state at scanning for the 33 BD and 31 healthy comparison (HC) participants. Symptoms were assessed using the Hamilton Depression Rating Scale (28) and Clinician-Administered Rating Scale for Mania (29). No subject had a history of neurologic illness, head trauma with loss of consciousness over 5 min, or major medical disorder with the exception of three
Results
There were no significant group differences in mean reaction time or response accuracy to the different face types (Table 1). We observed decreased pACC-amygdala functional connectivity in the BD group, compared with the HC group (p < .005), during fearful (Figure 1A and 1C) and happy (Figure 1B and 1D) face processing. No significant group differences in functional connectivity were detected during neutral face processing. Whole-brain analyses revealed additional group differences in
Discussion
We detected disturbances in pACC-amygdala functional connectivity during the processing of faces depicting positive and negative emotions in BD. Moreover, we found an association between pACC-amygdala functional connectivity measurements and the structural integrity of ventrofrontal white matter, including the uncinate fasciculus where FA was also significantly decreased in the BD group. Taken together, these data provide some of the first evidence that abnormalities in the structural integrity
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