Archival ReportProspective Association Between C-Reactive Protein and Fatigue in the Coronary Artery Risk Development in Young Adults Study
Section snippets
Subjects
The CARDIA study is a longitudinal study of cardiovascular risk factors in white and African American men and women aged 18 to 30 years at study inception. Full details of the study design and methods have been published previously (29). Briefly, 5115 individuals were recruited from four US cities (Birmingham, Alabama; Chicago, Illinois; Minneapolis, Minnesota; and Oakland, California) to take part in the baseline clinical examination (1985–1986). Of the 5115 individuals originally enrolled at
Baseline Characteristics
Overall, mean fatigue score and median CRP concentration at baseline were 1.93 (standard deviation 1.15) and 1.36 mg/L (interquartile range .53–3.72), respectively (Figure 1 in Supplement 1). Fatigue score of 1.93 indicates “a lot of energy during a good bit of the time.” Table 1 describes characteristics of the participants by levels of fatigue at baseline. A higher level of fatigue was associated with lower education level, higher BMI, more severe pain, lower physical activity level, higher
Discussion
In a community sample, higher plasma CRP concentration predicted higher fatigue level 5 years later independent of a series of risk factors, such as BMI, depressive symptoms, sleep quality, pain, and physical activity. To our knowledge, this is the first study to demonstrate a prospective association between a marker of systemic inflammation and fatigue in a general population. In addition, among participants without comorbid medical disorders, the association between CRP and fatigue was
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2018, Journal of Psychosomatic ResearchCitation Excerpt :CRP is an acute phase protein that is produced by hepatocytes in response to acute infection or injury, and is known to be a sensitive marker of chronic, low-grade inflammation [40]. Importantly, CRP has been associated with fatigue in other clinical populations [17, 41–43] and is a prognostic factor of heart disease [44]. Elevated levels of CRP are one of the strongest prognostic factors in atherosclerosis and cardiovascular events [45, 46].
Plasma leptin concentration is associated with fatigue severity in patients with cardiovascular risk factors – HSCAA study
2016, PsychoneuroendocrinologyCitation Excerpt :Fatigue is observed in about 20% of individuals in community populations, with women more prone to complain of that condition than men (Cho et al., 2009; Pawlikowska et al., 1994). Recent epidemiological studies have shown that fatigue is more common in patients with cardiovascular risk factors, such as obesity (Lim et al., 2005), diabetes (Drivsholm et al., 2005), smoking habit (Cho et al., 2009), sleep apnea (Bardwell et al., 2003), and chronic kidney disease (CKD) (Macdonald et al., 2012), as well as in those with previous cardiovascular events (Bunevicius et al., 2012; Kuppuswamy et al., 2015). Importantly, an elevated fatigue level is predictive of cardiovascular outcome, as we previously reported in a study of patients undergoing hemodialysis (Koyama et al., 2010).
Sleep disturbance and longitudinal risk of inflammation: Moderating influences of social integration and social isolation in the Coronary Artery Risk Development in Young Adults (CARDIA) study
2015, Brain, Behavior, and ImmunityCitation Excerpt :After this exclusion, 2962 participants remained. Sleep disturbance was assessed at baseline (2000–2001) using a sleep questionnaire specifically devised for the CARDIA study (Cho et al., 2012, 2009; St-Onge et al., 2010). A summary score was produced summing up 6 items of the sleep questionnaire (score range 0–9), with higher summary scores reflecting sleep disturbance as indexed by 6 components: daytime sleepiness (individual score 0 or 1); sleep onset problem (0 or 1); sleep maintenance problem (0 or 1); early awakening (0 or 1); subjective sleep quality (0–4); and short sleep duration (0 or 1).
Fatigue symptoms relate to systemic inflammation in patients with type 2 diabetes
2012, Brain, Behavior, and Immunity