Archival ReportFunctional Connectivity Bias of the Orbitofrontal Cortex in Drug-Free Patients with Major Depression
Section snippets
Subjects
Twenty-five patients with major depression were recruited from the Department of Psychiatry of the Ludwig-Maximilian University, Munich (Table 1). Psychiatric diagnoses were based on DSM-IV criteria and the Structured Clinical Interview for DSM-IV and determined by a consensus of at least two psychiatrists. All patients were antidepressant free: 16 patients had never received antidepressant medication; nine patients had received antidepressant medications during a previous episode but not
Results
There were no significant differences in age, sex, or weight between the patients and healthy control subjects (Table 1). Patients and control subjects showed no differences in the number of correct responses or reaction time in the explicit, implicit or comparison conditions. No significant differences were detected between connectivity of the left and right OFC.
Discussion
Our study demonstrates an altered connectivity between the OFC and other brain regions of the emotion-processing circuit in untreated patients with major depression. In particular, we found that connectivity between the OFC and right dorsolateral prefrontal cortex, right inferior frontal operculum, left motor regions, and left angular cortex was increased in patients than in control subjects but lower in patients in the middle ACC, precuneus, cerebellum, and right thalamus.
Structural
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2023, Behavioural Brain ResearchCitation Excerpt :Most consistent findings include hypoconnectivity within the frontoparietal network, hypoconnectivity between frontoparietal systems and parietal regions of the dorsal attention network involved in attending to the external environment, and hypoconnectivity between regions involved in processing emotion or salience and midline cortical regions. Moreover, MDD seems associated with hyperconnectivity within the default network (DMN), a network believed to support internally oriented and self-referential thought, and hyperconnectivity between frontoparietal control systems and regions of the DMN ([7-11], Meta-analysis [12]). Different factors are linked to a greater vulnerability for developing MDD such as childhood traumatization (CT) and adverse childhood experiences [13].
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