Archival ReportNeuroanatomic Predictors to Prodromal Psychosis in Velocardiofacial Syndrome (22q11.2 Deletion Syndrome): A Longitudinal Study
Section snippets
Participants
One hundred fifty-six participants were enrolled in the longitudinal study of risk factors for psychosis in VCFS. Recruitment methods were described previously (29). Families of children with cytogenetically confirmed VCFS were recruited from the VCFS International Center at SUNY Upstate Medical University. Unaffected siblings of VCFS participants were included as a separate study group to account for potential familial effects on development. Community control subjects were recruited through
Sample Characteristics
At Time 1, 86 youth with VCFS (mean age = 11.9 years, SD = 2.1), 33 siblings of youth with VCFS (sibling control; mean age = 12.3 years, SD = 2.0) and an age- and sex-matched group of 37 community control subjects (mean age = 12.1 years, SD = 1.8) participated. No age [F(2,155) = .55, p = .575, η2 = .007] or sex [χ2 (df = 2) = 2.78, p = .25] differences existed between the groups at Time 1.
One hundred twenty-two youth returned for Time 2 follow-up. Time 2 participants included 72 youth with
Discussion
In this longitudinal study, we observed that at Time 1, adjusted volumes of frontal gray and white matter, amygdala, and lateral ventricles were increased in participants with VCFS relative to siblings and control subjects, whereas adjusted volumes of occipital gray and white matter and cerebellum were decreased. Neuroanatomic trajectories between Times 1 and 2 were comparable among groups for most regions of interest, except cranial gray matter, which decreased in siblings but not control
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Cited by (69)
A Comprehensive Analysis of Cerebellar Volumes in the 22q11.2 Deletion Syndrome
2023, Biological Psychiatry: Cognitive Neuroscience and NeuroimagingNeuroimaging Phenotypes Associated With Risk and Resilience for Psychosis and Autism Spectrum Disorders in 22q11.2 Microdeletion Syndrome
2021, Biological Psychiatry: Cognitive Neuroscience and NeuroimagingAbnormalities in white matter tracts in the fronto-striatal-thalamic circuit are associated with verbal performance in 22q11.2DS
2020, Schizophrenia ResearchCitation Excerpt :An overview of the medication use at the time of the scan is given in Table 1. All details of the study, including exclusion criteria, are described in Kates et al. (2011). Participants were recruited from the International Center for Evaluation, Treatment, and Study of Velo-Cardio-Facial Syndrome at SUNY Upstate Medical University, Syracuse, NY, from parent support groups, and from the surrounding community by the team directed by Dr. Wendy Kates.
Meta-analysis of olfactory dysfunction in 22q11.2 deletion syndrome
2020, Psychiatry ResearchSystematic review and multi-modal meta-analysis of magnetic resonance imaging findings in 22q11.2 deletion syndrome: Is more evidence needed?
2019, Neuroscience and Biobehavioral ReviewsCitation Excerpt :Critically, the current work highlighted that besides the work of Sun et al. (Sun et al., 2018), only 2 imaging studies so far have directly investigated the differences in brain structure and function in 22q11.2 DS individuals with and without psychosis (van Amelsvoort et al., 2004; Dufour et al., 2008). Furthermore, only 9 studies adopted a longitudinal design to investigate whether and how brain structural and functional abnormalities change over time in 22q11.2 adults with and without psychosis (Gothelf et al., 2011; Schaer et al., 2009; Kates et al., 2011a, b; Flahault et al., 2012; Kunwar et al., 2012; Sandini et al., 2018; Gothelf et al., 2007b; Berhanu et al., 2017). This is surprising, since 22q11.2 DS is considered the most robust genetic model of vulnerability to psychosis.