Archival ReportAt-Risk Variant in TCF7L2 for Type II Diabetes Increases Risk of Schizophrenia
Section snippets
Danish Discovery Sample
Four hundred twenty patients from the Danish Psychiatric Biobank diagnosed with International Classification of Diseases (ICD) Version 10 F20 or F25 and with no history of bipolar disorder (F30–31) were used as the discovery sample (37). For each patient, two healthy control subjects were selected among 15,000 donors in the Danish Blood Donor Corps (> 5% of the Danish population) from the same Copenhagen area as the patients. They were matched to the patients on sex and year/month of birth. At
Frequencies and Hardy–Weinberg Equilibriums
Eleven SNPs associated with T2D in GWAS before this study (published before 2008) were genotyped in the Danish sample. The allele frequencies correspond to those described in dbSNP and HapMap for Caucasians. The observed genotype distribution was not significantly different from that expected under Hardy–Weinberg proportions after correction for multiple testing (Table 1), with the exception of the SNP rs7756992 in CDKAL1 in cases (p = .002). Thus, all 11 SNPs were tested for association to
Discussion
To the best of our knowledge, this study is the first attempt to use known genetic risk factors for an epidemiologic or clinical condition to analyze a shared etiology between a somatic and a psychiatric disorder. Prompted by the increased incidence of T2D among schizophrenia patients, we analyzed the risk conferred by known T2D susceptibility variants for developing schizophrenia.
The T2D at-risk SNP in TCF7L2 (rs7903146 [T]), but not the other 10 examined T2D at-risk alleles, was associated
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