Archival ReportVariation in the Oxytocin Receptor Gene Is Associated with Pair-Bonding and Social Behavior
Section snippets
Methods and Materials
An overview of the different study samples, including information about the phenotypes and the order of analyses, is presented in Figure 1. More extensive descriptions of the samples and measures used are presented in the following text as well as in Supplement 1.
Results
Twelve OXTR SNPs, evenly distributed over the gene and previously proposed to be associated with autism and other aspects of social behaviors (Table 1), were genotyped in the adult men and women from the TOSS study (n = 2309) (50) and in the participants of the TCHAD study (n = 1240) sample (53). The allele and genotype distributions of the studied SNPs were similar to what has been reported in previous studies and did not deviate from Hardy-Weinberg equilibrium.
Our first set of analyses
Discussion
Our current results propose an association between an SNP in OXTR (rs7632287) and pair-bonding behavior in adult and adolescent women as well as with measures of social problems in childhood, both reflected through normal variation in behavior as well as with measures of autism spectrum traits. The rs7632287 SNP was significantly associated with two different measures of pair-bonding related behaviors, including the PBS as well as the affection subscale from the RQS. Furthermore, when
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