Inhibitors of hepatitis C virus NS3·4A protease 1. Non-Charged tetrapeptide variants

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Abstract

Tetrapeptide-based peptidomimetic compounds have been shown to effectively inhibit the hepatitis C virus NS3·4A protease without the need of a charged functionality. An aldehyde is used as a prototype reversible electrophilic warhead. The SAR of the P1 and P2 inhibitor positions is discussed.

The synthesis and structure–activity relationships of a novel series of reversible covalent inhibitors of the hepatitis C NS3·4A protease are described.

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