Anti-tumor abietane diterpenes from the cones of Sequoia sempervirens
Graphical abstract
New 20-hydroxyferruginol (1) was isolated from the cones of Sequoia sempervirens. Their structures were elucidated by spectral data. Compound 1 strongly inhibited human tumor cells.
Section snippets
Acknowledgements
This work was supported by Plant Diversity Research Center (PF0320506-0) of the 21st Century Frontier Research Program and the KRIBB Research Initiative Program.
References and notes (16)
- et al.
Tetrahedron Lett.
(2002) - et al.
Tetrahedron
(2000) - et al.
Bioorg. Med. Chem.
(2003) - et al.
Tetrahedron
(2003) - et al.
Phytochemistry
(2005) - et al.
J. Org. Chem.
(2002) - et al.
Planta Med.
(2003)
Cited by (72)
Application of cold plasma pretreatment to improve the extraction efficiency of tanshinone compounds from Salvia subg. Perovskia root
2023, Industrial Crops and ProductsA Biomimetic Stereoselective Approach to Euolutchuol C and Its Structural Assignment
2023, European Journal of Organic ChemistryDehydroicetexanes in sediments and crude oils: Possible markers for Cupressoideae
2019, Organic GeochemistrySynthesis of new sarsasapogenin derivatives with antiproliferative and apoptotic effects in MCF-7 cells
2018, SteroidsCitation Excerpt :Despite advances in modern drug discovery technologies, natural products are still an important source for the new chemotherapeutic agents [2]. Many natural or natural based antitumor drugs such as taxol, vinblastine, bleomycin and doxorubicin derivatives have been clinically used in recent years [3–5]. Naturally occurring steroids have been shown to possess a variety of biological activities and provide privileged structures for further modifications and structure-activity relationship studies [6,7].