Anti-tumor abietane diterpenes from the cones of Sequoia sempervirens

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Abstract

A new abietane, namely, 20-hydroxyferruginol (1), together with known ferruginol (2), 18-hydroxyferruginol (3), sugiol (4), and 6α-hydroxysugiol (5), were isolated from the cones of Sequoia sempervirens. Their structures were elucidated through spectral data. Compounds 1 and 5 strongly inhibited colon, lung, and breast human tumors and oncogene transformed cells with GI50 2–5 μg/mL.

Graphical abstract

New 20-hydroxyferruginol (1) was isolated from the cones of Sequoia sempervirens. Their structures were elucidated by spectral data. Compound 1 strongly inhibited human tumor cells.

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Acknowledgements

This work was supported by Plant Diversity Research Center (PF0320506-0) of the 21st Century Frontier Research Program and the KRIBB Research Initiative Program.

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