Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors

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Abstract

A series of rhodanine derivatives was synthesized and evaluated for their ability to inhibit PRL-3. Benzylidene rhodanine derivative showed good biological activity, while compound 5e was the most active in this series exhibiting an IC50 value of 0.9 μM in vitro and showed a reduced invasion in cell-based assay.

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Acknowledgments

We thank the cooperation of Korea Chemical Bank to use chemical library for HTS (http://www.chembank.or.kr). This study was supported by Ministry of Commerce, Industry and Energy (MOCIE).

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These authors contributed equally to this work.

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