Hepatoprotective activity of Schouwia thebica webb
Graphical abstract
Oral administration of alcoholic extract of Schouwia thebica Webb showed that extracts are safe for human use, since it failed to induce death of mice in doses up to 4000 mg/kg body weight Hepatoprotective activity of the total alcoholic, diethyl ether, chloroform, ethyl acetate and n-butanol extracts were tested. It was found that the ethyl acetate and n-butanol extracts showed hepatoprotective activity. These extracts significantly reduced the increase in activities of ALT, AST, GGT, levels of glucose, triglycerides and cholesterol in serum of CCl4 treated rats. The extracts showing hepatoprotective activity were found to contain a new flavonoid chrysoeriol-7-O-β-D-xylopyranoside-(1-2)-arabinofuranoside which was mainly found to be responsible for this activity when tested on lab animals alongside four flavonoids, known as chrysoeriol, Quercetin, quercetin-7-O-rhamnoside and kaempferol-3-O-β-D-glucoside. The structures were established by different spectroscopic techniques.
Section snippets
Acknowledgment
The NMR spectroscopic identification of the flavonoids was facilitated through the use of ACD/Structure Elucidator, version 8, Advanced Chemistry Development, Inc. (ACD/Labs), Toronto, ON, Canada, www.acdlabs.com, 2006. DJM acknowledges with thanks the use of dedicated 1H and 13C NMR databases also available from ACD/Labs.
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