Macrocyclic chelator assembled RGD multimers for tumor targeting

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Abstract

Macrocyclic chelators have been extensively used for complexation of metal ions. A widely used chelator, DOTA, has been explored as a molecular platform to assemble multiple bioactive peptides in this paper. The multivalent DOTA-peptide bioconjugates demonstrate promising tumor targeting ability.

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Acknowledgments

This work was supported in part by the National Cancer Institute (NCI) grant R01 CA119053 (to Z.C.) and a China Scholarship Council fellowship (to X.Z.).

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