CASE REPORTIntracystic papillary carcinoma of the breast in a male patient diagnosed by core needle biopsy: a case report
Introduction
Male breast cancer is an uncommon disease with an incidence of approximately 1% of all breast cancers.1 Intracystic papillary carcinoma (IPC) forms a small subgroup of breast carcinomas with a favorable prognosis.2, 3 Core needle biopsy has been increasingly utilized as initial approach for the diagnosis of mammographic abnormalities and palpable breast lesions. In this report, we describe a case of mammary IPC diagnosed in a 71-year-old man by core needle biopsy. We discuss the clinicopathological features of cystic breast cancer in the male and review the literature and the present case.
Section snippets
Case report
A 71-year-old man, complaining of a round mass in his subareolar region with bloody nipple discharge, visited the National Cancer Center Hospital in October 2003. He had a past history of lung cancer and gastric cancer. There was no reported history of breast trauma. He had gynecomastia in his right breast. The tumor was 6×5 cm2 in size with a smooth surface and clear margin. No overlying skin retraction and no palpable axillary lymph nodes were noted.
Mammogram revealed a 6 cm lobulated mass in
Pathologic findings
The specimen consisted of a simple mastectomy with an overlying ellipse skin with nipple. A 4.1×2.0 cm2 well-circumscribed, partially hemorrhagic cystic mass was identified under the areola. At lower-power magnification, the cyst wall was lined by multilayered flat epithelial cells, and papillary epithelial lesions with a fibrous stalk present in the wall (Fig. 4A).
At higher magnification, this solid papillary proliferation is composed of neoplastic cells with mild nuclear atypia and a high
Discussion
IPC of the breast in the male is a very rare disease and it also shows a good prognosis. IPC represents a small subgroup of breast cancers and accounts 0.5–2% of breast cancer in women.2 Some studies have suggested that they form a higher percentage in men, with an incidence range of 5–7.5%.4, 5 Furthermore, increased risk in men with gynecomastia has been reported.6 Pacelli,7 in a recent review of the literature, reported that nine patients underwent fine-needle aspiration, but only four cases
References (12)
Disease of the breast
(1986)Intracystic carcinoma of female breast
Surg Gynecol Obstet
(1967)- et al.
Intracystic papillary carcinoma of the breast after mastectomy, radiotherapy or excision biopsy alone
Cancer
(1983) - et al.
Male breast cancerclinicopathologic study of 97 cases
Ann Surg
(1978) - et al.
Breast cancer in malesclinicopathologic study of 40 patients
(1981) - et al.
Cancer of the male breastforty cases
Cancer
(1967)