Clinical InvestigationHigh Serum Level of Pentosidine, an Advanced Glycation End Product (AGE), is a Risk Factor of Patients with Heart Failure
Section snippets
Study Subjects
We measured serum concentration of pentosidine in 141 patients (88 male and 53 female, mean age 66 ± 13 years) who admitted to the Yamagata University Hospital for diagnosis or treatment of heart failure and 18 age-matched control subjects (8 male and 10 female, mean age 64 ± 13 years). The diagnosis of heart failure was based on a history of dyspnea and symptomatic exercise intolerance with signs of pulmonary congestion or peripheral edema or documentation of left ventricular enlargement or
Results
Baseline clinical characteristics of patients with heart failure and control subjects are shown in Table 1. B-type natriuretic peptide (BNP), uric acid, LVEDD, LVESD, IVS, PW, EDV, ESV, and LV mass were significantly higher in patients with heart failure than in control subjects. EF was significantly lower in patients with heart failure than in control subjects. As shown in Fig. 1, pentosidine concentration was significantly increased in patients with NYHA Class III/IV than in control subjects
Discussion
In the present study, we showed that serum pentosidine level was higher in patients with severe heart failure with NYHA functional Class III/IV than in those with mild heart failure with NYHA Class I/II. Pentosidine level was also higher in patients with cardiac events than in those without events. Multivariate Cox proportional hazard analysis demonstrated that pentosidine was the most powerful factor to predict adverse clinical outcomes in patients with heart failure. The highest quartile of
Conclusions
Serum pentosidine concentration is related to the severity of heart failure and is an independently risk factor to predict adverse clinical outcomes in patients with heart failure. Pentosidine may be a novel marker for risk stratification of patients with heart failure.
References (35)
- et al.
Predictors of congestive heart failure in the elderly: the Cardiovascular Health Study
J Am Coll Cardiol
(2000) - et al.
Oxidative stress in brain aging, neurodegenerative and vascular diseases: an overview
J Chromatogr B Analyt Technol Biomed Life Sci
(2005) - et al.
Clearance of pentosidine, an advanced glycation end product, by different modalities of renal replacement therapy
Kidney Int
(1997) Advanced glycation endproducts—role in pathology of diabetic complications
Diabetes Res Clin Pract
(2005)- et al.
Renal catabolism of advanced glycation end products: the fate of pentosidine
Kidney Int
(1998) - et al.
Prognostic value of elevated circulating heart-type fatty acid binding protein in patients with congestive heart failure
J Card Fail
(2005) - et al.
Cystatin C, a novel measure of renal function, is an independent predictor of cardiac events in patients with heart failure
J Card Fail
(2005) - et al.
Mechanism of formation of the Maillard protein cross-link pentosidine. Glucose, fructose, and ascorbate as pentosidine precursors
J Biol Chem
(1991) - et al.
Formation of pentosidine during nonenzymatic browning of proteins by glucose. Identification of glucose and other carbohydrates as possible precursors of pentosidine in vivo
J Biol Chem
(1991) - et al.
The oxidative stress hypothesis of congestive heart failure: radical thoughts
Chest
(2001)
Increased reactive oxygen species production and functional alterations in antioxidant enzymes in human failing myocardium
J Card Fail
Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins
J Biol Chem
Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins
J Biol Chem
High molecular weight hyaluronic acid inhibits advanced glycation endproduct-induced NF-kappaB activation and cytokine expression
FEBS Lett
Cardiovascular and renal effects of a collagen cross-link breaker (ALT 711) in adult and aged spontaneously hypertensive rats
Am J Hypertens
The effect of alagebrium chloride (ALT-711), a novel glucose cross-link breaker, in the treatment of elderly patients with diastolic heart failure
J Card Fail
Cytokine gene expression after myocardial infarction in rat hearts: possible implication in left ventricular remodeling
Circulation
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This study was supported in part by a grant-in-aid for Scientific Research (No. 17590702) from the Ministry of Education, Science, Sports and Culture, Japan, a grant-in-aid from the 21st Century Center of Excellence (COE) program of the Japan Society for the Promotion of Science, and grants from Takeda Science Foundation and Fukuda Foundation for Medical Technology.