Cancer Cell
Volume 18, Issue 1, 13 July 2010, Pages 63-73
ArticleA Synthetic Lethal Interaction between K-Ras Oncogenes and Cdk4 Unveils a Therapeutic Strategy for Non-small Cell Lung Carcinoma
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Highlights
► Ablation of Cdk4 induces a senescence response in cells expressing a K-Ras oncogene ► This synthetic lethal interaction is exquisitely specific for lung cells ► Loss of Cdk4 prevents progression of advanced CT+ lung adenocarcinomas ► A selective CDK4 inhibitor has significant therapeutic activity against these tumors
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These authors contributed equally to this work
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Present address: Koch Institute for Integrative Cancer Research at MIT, 77 Massachusetts Avenue, E17-227, Cambridge, MA 02139, USA
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Present address: Instituto de Investigaciones Biomédicas “Alberto Sols,” CSIC, Arturo Duperier 4, 28029 Madrid, Spain
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