Cancer Cell
Volume 21, Issue 1, 17 January 2012, Pages 11-24
ArticleSelf-Renewal Does Not Predict Tumor Growth Potential in Mouse Models of High-Grade Glioma
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Graphical Abstract
Highlights
► Id1 identifies self-renewing glioma cells ► Self-renewal is not required for glioma growth in PDGF- and KRAS-driven tumors ► Purified progenitor cells efficiently transplant gliomas ► Id1 high self-renewing cells can generate aggressive progenitors
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Present address: Howard Hughes Medical Institute and Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
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