Cell
Volume 119, Issue 1, 1 October 2004, Pages 5-7
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PGC-1α: Turbocharging mitochondria

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Abstract

PGC-1α plays essential and diverse functions in the control of metabolism ranging from mitochondrial biogenesis and respiration to hepatic gluconeogenesis and muscle fiber-type switching. In a paper by Lin et al. (2004)(this issue of Cell), the characterization of PGC-1α−/− mice illustrates these pleiotropic functions and reveals an unexpected role for PGC-1α in the brain.

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