Cell
Volume 122, Issue 1, 15 July 2005, Pages 17-20
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RNAi: The Nuts and Bolts of the RISC Machine

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Research on RNA interference and microRNA pathways continues to accelerate. Combinations of biochemical, genetic, and structural approaches are providing new insights into the mechanism by which small, ∼21 nt long RNAs find their way into the RISC effector complexes and how the RISCs execute their mission of RNA-guided posttranscriptional gene silencing.

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