Cell
Volume 126, Issue 1, 14 July 2006, Pages 27-29
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OPA1 and PARL Keep a Lid on Apoptosis

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A change in the shape of mitochondrial cristae must take place to attain rapid and complete release of cytochrome c during apoptosis. In this issue of Cell, Cipolat et al. (2006) and Frezza et al. (2006) show that a rhomboid intramembrane protease PARL and a dynamin-related protein OPA1 are critical regulators of cristae remodeling.

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