Cell
Volume 130, Issue 2, 27 July 2007, Pages 223-233
Journal home page for Cell

Review
Cellular Senescence in Cancer and Aging

https://doi.org/10.1016/j.cell.2007.07.003Get rights and content
Under an Elsevier user license
open archive

Cellular senescence, a state of irreversible growth arrest, can be triggered by multiple mechanisms including telomere shortening, the epigenetic derepression of the INK4a/ARF locus, and DNA damage. Together these mechanisms limit excessive or aberrant cellular proliferation, and so the state of senescence protects against the development of cancer. Recent evidence suggests that cellular senescence also may be involved in aging.

Cited by (0)