Cell
Volume 138, Issue 1, 10 July 2009, Pages 14-16
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Teeing Up Transcription on CpG Islands

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Eukaryotic cells use elaborate molecular mechanisms to rapidly activate signal-dependent gene expression. New work provides fresh insights into these mechanisms by demonstrating that CpG islands in promoters are nucleosome-destabilizing elements and can facilitate the establishment of an unusual poised transcriptional state (Ramirez-Carrozzi et al., 2009, Hargreaves et al., 2009).

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