Cell
Volume 140, Issue 2, 22 January 2010, Pages 246-256
ArticleStructural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1
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Graphical Abstract
Highlights
► The structure is determined of the five-domain autoinhibitory element of Vav1 ► The Vav1 Dbl homology domain is inhibited by cooperative interdomain interactions ► Inhibition is relieved in stepwise fashion by phosphorylation ► The energetics of multidomain systems enable strong inhibition and rapid activation
SIGNALING
Cited by (0)
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These authors contributed equally to this work
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Present address: Department of Biochemistry, Biophysics, and Molecular Biology, 4210 Molecular Biology Building, Iowa State University, Ames, IA 50011, USA
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Present address: University of North Carolina, School of Medicine, Chapel Hill, NC 27599, USA
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