Cell
Volume 142, Issue 5, 3 September 2010, Pages 661-667
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Essay
Phosphotyrosine Signaling: Evolving a New Cellular Communication System

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Tyrosine phosphorylation controls many cellular functions. Yet the three-part toolkit that regulates phosphotyrosine signaling—tyrosine kinases, phosphotyrosine phosphatases, and Src Homology 2 (SH2) domains—is a relatively new innovation. Genomic analyses reveal how this revolutionary signaling system may have originated and why it rapidly became critical to metazoans.

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