Cell
Volume 144, Issue 4, 18 February 2011, Pages 465-466
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Targeting Aneuploidy for Cancer Therapy

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Tumor cells frequently display an abnormal number of chromosomes, a phenomenon known as aneuploidy. Tang et al. (2011) now show that aneuploid cells are particularly sensitive to compounds that induce proteotoxic and energy stress. Could this vulnerability lead to new cancer therapies?

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