Cell
Volume 148, Issue 4, 17 February 2012, Pages 639-650
ArticleTAK1 Inhibition Promotes Apoptosis in KRAS-Dependent Colon Cancers
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Graphical Abstract
Highlights
► The TAK1 kinase promotes survival of KRAS-dependent colon cancer cells ► TAK1 dependency correlates with KRAS-mediated activation of Wnt signaling ► KRAS activates Wnt signaling via TAK1 in APC-deficient cancer cells ► KRAS upregulates BMP signaling, leading to increased TAK1 kinase activity
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Present address: Department of Pharmacology and Experimental Therapeutics, Division of Medical Oncology and Hematology, Cancer Research Center, Boston University School of Medicine, Boston, MA 02118, USA
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Present address: Discovery Oncology, Genentech, Inc., South San Francisco, CA 94080, USA
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