Cell
Volume 151, Issue 7, 21 December 2012, Pages 1557-1568
ArticleCrystal Structure of the HLA-DM–HLA-DR1 Complex Defines Mechanisms for Rapid Peptide Selection
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Graphical Abstract
Highlights
► Structure of HLA-DM-HLA-DR1 complex identifies key steps in antigen presentation ► Two aromatic HLA-DR residues move in and stabilize the hydrophobic P1 pocket ► Occlusion of P1 pocket enables rapid selection of high-affinity peptides ► Only peptides that successfully compete for the P1 pocket are stably bound
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These authors contributed equally to this work
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Present address: The Walter and Eliza Hall Institute of Medical Research, Parkville VIC 3052, Australia
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