Original articleIn Vivo Histology of Barrett’s Esophagus and Associated Neoplasia by Confocal Laser Endomicroscopy
Section snippets
Confocal Laser Endoscope
The components of the confocal laser endoscope are based on the integration of a confocal laser microscope in the distal tip of a conventional video endoscope (joint venture between Pentax, Tokyo, Japan, and Optiscan, Victoria, Australia), which enables confocal microscopy in addition to standard video endoscopy. The diameter of the distal tip and the insertion tube was 12.8 mm. The distal tip contained an air and water jet nozzle, 2 light guides, an auxiliary water jet channel (used for
Results
A total of 75 consecutive patients were screened for possible inclusion in the present study, 12 of whom were excluded. A total of 63 patients fulfilled all inclusion criteria and were enrolled in this study, which was conducted between January 2004 and March 2005. All patients completed the study protocol (44 men, 19 women; age, 58.7 ± 16.3 y) including upper endoscopy plus confocal laser endomicroscopy (Figure 1). Indications consisted of long-lasting reflux symptoms (20 patients),
Discussion
In vivo confocal laser endomicroscopy is a newly developed tool that enables subsurface imaging of living cells in the mucosa during ongoing endoscopy. It offers the possibility to combine video endoscopy and confocal endomicroscopy.13 In the present article, we report about the use of this confocal laser endoscope in human beings to facilitate detection of Barrett’s epithelium and Barrett’s-associated neoplasia.
Modern endoscopy recently has seen many major technical improvements including the
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Cited by (0)
R.K. and L.G. contributed equally to this paper.