Cell Metabolism
Volume 2, Issue 6, December 2005, Pages 344-345
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Osteoprotegerin, the bone protector, is a surprising target for β-catenin signaling

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Osteoblasts influence bone mass by the amount of bone they synthesize and by regulating osteoclasts, the cells that degrade bone. In the December issue of Developmental Cell, Kieslinger et al. (2005) show that immature osteoblasts regulate expression of the osteoclast inhibitor, osteoprotegerin, through an early B cell factor and β-catenin signaling.

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