Nano-emulsions
Introduction
Emulsions with droplet size in the nanometric scale (typically in the range 20–200 nm) are often referred to in the literature as miniemulsions [1], nano-emulsions [2], [3], ultrafine emulsions [2], submicron emulsions [4], etc. The term nano-emulsion [5•], [6•] is preferred because in addition to give an idea of the nanoscale size range of the droplets it is concise and it avoids misinterpretation with the term microemulsion (which are thermodynamically stable systems). Due to their characteristic size, nano-emulsions appear transparent or translucent to the naked eye (Fig. 1) and possess stability against sedimentation or creaming. These properties make nano-emulsions of interest for fundamental studies and for practical applications (e.g. chemical, pharmaceutical, cosmetic, etc. fields). Oil-in-water (O/W) type nano-emulsions have been investigated since long ago, and have been reviewed thoroughly [1], [4], [5•], [6•], [7], [8••], [9•], specially as nanoreactors for polymerization [7], [8••], [9•]. In contrast, water-in-oil (W/O) nano-emulsions have been described for the first time recently [10••], [11••]. Both types of nano-emulsions are experiencing a very active development as reflected by the numerous publications and patents. In this review, the attention is mainly focused to nano-emulsion formation, with special emphasis on low-energy emulsification methods. Some recent contributions on nano-emulsion properties and applications are also discussed.
Section snippets
Nano-emulsion formation
Nano-emulsions, being non-equilibrium systems, cannot be formed spontaneously. Consequently, energy input, generally from mechanical devices or from the chemical potential of the components, is required. Nano-emulsion formation by the so-called dispersion or high-energy emulsification methods is generally achieved using high-shear stirring, high-pressure homogenizers and ultrasound generators. It has been shown that the apparatus supplying the available energy in the shortest time and having
Stability
The small droplet size of nano-emulsions confers stability against sedimentation (or creaming) because the Brownian motion and consequently the diffusion rate are higher than the sedimentation (or creaming) rate induced by the gravity force. Ostwald ripening or molecular diffusion, which arises from emulsion polydispersity and the difference in solubility between small and large droplets, is the main mechanism for nano-emulsion destabilization [6•]. The Lifshitz–Slezov [40] and Wagner [41]
Applications
The small droplet size, high kinetic stability and optical transparency of nano-emulsions compared to conventional emulsions, give them advantages for their use in many technological applications. The majority of publications on nano-emulsion applications deal with the preparation of polymeric nanoparticles using a monomer as the disperse phase (the so-called miniemulsion polymerization method) [7], [8••], [9•]. In contrast to emulsion and microemulsion polymerization, in nano-emulsion
Conclusions
The study of basic and applied aspects of nano-emulsions is receiving increasing attention in recent years. Dispersion or high-energy emulsification methods are traditionally used for nano-emulsion formation. However, nano-emulsions are also efficiently formed by condensation or low-energy methods. Nano-emulsion droplet sizes in the range of 20–200 nm and narrow size distributions are obtained in both methods. Studies on nano-emulsion formation by low-energy methods have shown that the size of
Acknowledgements
The authors acknowledge financial support by the Spanish Ministry of Education and Science, DGI (Grant PPQ2002-04514-CO3-03) and “Generalitat de Catalunya”, DURSI (Grant 2001SGR-00357).
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