Current Biology
Volume 22, Issue 16, 21 August 2012, Pages 1510-1515
ReportExo70 Stimulates the Arp2/3 Complex for Lamellipodia Formation and Directional Cell Migration
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Highlights
► Exo70 kinetically stimulates the Arp2/3 complex-mediated actin assembly ► The Exo70-ARPC1 interaction is required for stimulating the Arp2/3 complex ► Exo70 promotes the interaction between the Arp2/3 complex and WAVE2 ► The Exo70-Arp2/3 interaction regulates lamellipodia formation and cell migration
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These authors contributed equally to this work
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Present address: Biodynamic Optical Imaging Center, Peking University, Beijing 100871, China
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Present address: Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
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