Gene polymorphisms in pro-inflammatory cytokines are associated with systemic inflammation in patients with severe periodontal infections
Section snippets
Demographics and periodontal infection
Fifty-four percent of subjects were females; they were 46 ± 9 years of age, 42% were current smokers, and their body mass index was 25.3 ± 3.8 kg/m2. In terms of ethnicity 65% of subjects were European Caucasians, 20% Asians and 15% African or Afro-Caribbeans. All subjects included had severe generalized periodontitis as indicated by mean full mouth CAL of 4.9 ± 1.1 mm, PPD of 4.4 ± 0.6 mm, presence of 77 ± 23 periodontal pockets >4 mm, and a full mouth bleeding score of 63.5% ± 16.4%. Infection was assessed
Discussion
The data reported in this study indicated that in patient with severe periodontitis, serum IL-6 concentrations were significantly associated with the carriage of allele 2 for functional polymorphisms in the IL-1A, TNF-A and IL-6 genes after correcting for age, gender, ethnicity and smoking status. Similarly, serum CRP concentrations were associated with allele 2 in the IL-1A and IL-6 genes. In the subject group no medical condition other than severe generalized periodontitis was detected
Experimental population
Ninety-four subjects referred to the Department of Periodontology of the Eastman Dental Hospital, University College London, for treatment of severe periodontitis gave informed consent to participate in this study. They were characterised by the presence of deep periodontal pockets (5 mm or deeper with radiographic evidence of alveolar bone loss) and bleeding upon probing involving more than 50% of the dentition. Subjects were examined at a screening visit and a full medical history was
Acknowledgements
This study was supported by the Periodontal Research Fund of the Eastman Dental Institute. The kind assistance of the clinical staff of the Department of Periodontology of the Eastman Dental Institute and Hospital, University College London, is gratefully acknowledged.
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