Mini ReviewDrosophila aging 2006/2007
Section snippets
Sleep
The fruit fly, Drosophila melanogaster, can be used as an effective model organism to study sleep (Hendricks et al., 2000, Shaw et al., 2000). Sleep in the fly is identified using behavioral criteria that were established in the days before the electroencephalogram became the standard for identifying sleep in mammals and birds. The criteria include: (1) prolonged periods of quiescence; (2) reduced responsiveness to external stimuli; (3) rapid reversibility, which distinguishes sleep from
Cardiomyopathies and arrhythmias
Novel methods for investigating fly heart function have recently become available that promise to dramatically expand the possibilities for screening mutants and for analysis of cardiac contractility and stress response in Drosophila (Wessells et al., 2004, Wolf et al., 2006, Ocorr et al., 2007a, Ocorr et al., 2007b). One method uses a non-contact echography, optical coherence tomography (OCT), discussed last year in Exp. Gerontol. (Lim et al., 2006), to image the contractions of the heart (
Coordination of tissue aging
Tissue and functional aging of organs is an important component of the regulation of organismal lifespan, yet the underlying regulation and coordination of these processes remains largely unknown. One mechanism influencing lifespan is genetic variation. For example, there are polygenic influences contributing to lifespan regulation (Wilson et al., 2006). Although many quantitative trait loci (QTLs) have been identified that contribute to the variation in longevity, how these QTLs functionally
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Cited by (28)
The aging brain: sleep, the circadian clock and exercise
2021, Biochemical PharmacologyCitation Excerpt :In contrast to the other two blocks of theories, the evolutionary aging theories have been developed, suggesting that following the reproductive age there is a decline in maintenance and repair mechanisms in the organisms that ultimately leads them into their end [2–5]. During the last decades, experiments on the fruit fly Drosophila melanogaster have been extensively performed in several fields, including aging research, and it was proposed for the first time that life span may also be an inherited trait [6–7]. The heritability of human longevity has been estimated to be interestingly low (∼15–30%), since life span generally integrates several aspects of health but also environment [8].
Absence of rapid eye movements during sleep in adult zebrafish
2015, Behavioural Brain ResearchCitation Excerpt :Possibly, REM components could be more easily detected in young fish or larvae. Young mammals (and even drosophila) have a greater ratio of REM to NREM sleep (and more sleep in total) than adults and therefore it might be possible to more easily identify REM components in young fish [10,16,22–24]. Previous studies have established a definition of zebrafish sleep as a period after the fish has been immobile longer than 6 s where the velocity of the fish at no point exceeds 1.5 cm/s [7–10,13].
Studying aging in Drosophila
2014, MethodsCitation Excerpt :While much attention has been paid to Drosophila models for neurodegenerative disorders [97–100], innate neurological changes in aging flies remain understudied. However, flies exhibit pronounced age-related changes in olfactory acuity and in circadian rhythm and sleep patterns [95,101,102], suggesting specific neurological or neurosecretory changes in the aging fly brain that also may affect lifespan [82,101,103]. Morphological characterization of changes in the aging brain has focused on the presence and number of dopaminergic neurons, which can be easily identified by anti-TH staining or using TH-Gal4 drivers [104,105].
High calorie diet augments age-associats sleep impairment in Drosophila
2012, Biochemical and Biophysical Research CommunicationsCitation Excerpt :However the fmn mutation alone revealed no effects on longevity, despite the short sleep phenotype (Fig. 1) [23]. Shaw et al. refer to the difference in the nature of the mutation as a possible explanation [3]. Our present results suggest another possibility; that the amount of sleep fmn mutants take when under good diet conditions is enough for their full survival.
Podocytes and Glomerular Function with Aging
2009, Seminars in NephrologyCurrent Animal Model Systems for Ovarian Aging Research
2022, Aging and Disease