Commentary
Is topiramate a potential therapeutic agent for cerebral hypoxic/ischemic injury?

https://doi.org/10.1016/j.expneurol.2006.09.014Get rights and content

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  • Cited by (14)

    • Pathophysiology

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    • Potential neuroprotective effects of continuous topiramate therapy in the developing brain

      2011, Epilepsy and Behavior
      Citation Excerpt :

      Importantly, these are two very different measures, yet they both indicate that activity levels are disturbed in these mice, including those who underwent intraperitoneal injections and those who did not. Protective effects of short-term TPM therapy have been demonstrated in many models of neuronal injury such as pilocarpine-induced status epilepticus (SE), flurothyl-induced SE, hypoxia/ischemia, retinal ischemia, stroke, and limbic SE induced by electrical stimulation [23–30]. Our study extends these observations to include chronic TPM therapy in the P10 hypoxia model.

    • Neuroprotection in Infant Heart Surgery

      2008, Clinics in Perinatology
      Citation Excerpt :

      Still, the observation that the nearly 20% PVL in preoperative MRIs increases to more than 50% postoperatively suggests that this may still be the most fruitful time period to attempt intervention. Topiramate is an attractive candidate for pharmacologic neuroprotection in the infant heart surgery population.55 It is an orally available anti-seizure medication that was approved by the US Food and Drug Administration to treat seizure disorders in the United States in 1996.

    • Pharmacotherapy and motor recovery after stroke

      2018, Expert Review of Neurotherapeutics
    • Pathophysiology: General Principles. General Principles.

      2017, Volpe's Neurology of the Newborn
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    Commentary on: Noh et al.'s “Neuroprotective effect of topiramate on hypoxic ischemic brain injury in neonatal rats”.

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