Elsevier

Fertility and Sterility

Volume 94, Issue 6, November 2010, Pages 2356-2358.e1
Fertility and Sterility

Correspondence
Aberrant DNA methylation of imprinted H19 gene in human preimplantation embryos

The preliminary results of this trial have been presented at the 65th American Society of Reproductive Medicine meeting, which was held in Atlanta, Georgia, in October 2009.
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DNA methylation patterns of the H19 differentially methylated region were successfully determined in 32 of 50 human day 3 embryos produced and discarded after assisted reproductive technology procedures. We found methylation patterns similar to those of somatic cells in 81.3% of embryos and demethylation or hypomethylation patterns in 18.7% of embryos.

Key Words

Assisted reproductive technologies
DNA methylation
H19
human embryos

Cited by (0)

Supported by National Key Basic Research Development Plan of China (973 Program) (2007CB948104).

S.-L.C. has nothing to disclose. X.-Y.S. has nothing to disclose. H.-Y.Z. has nothing to disclose. F.-R.W. has nothing to disclose. C.L. has nothing to disclose.

The first two authors contributed equally to this work.