Original articleBody mass index and short-term weight change in relation to treatment outcomes in women undergoing assisted reproduction
Section snippets
Study Population
Participants were women enrolled in the EARTH Study, an ongoing prospective cohort started in 2004 aimed at identifying environmental and nutritional determinants of fertility among couples presenting for infertility evaluation and treatment at the Massachusetts General Hospital Fertility Center. Women and men aged between 18 and 45 years using their own gametes for IUI or IVF were eligible to enroll in the study. Enrollment as a couple is not required for participation. Upon entry, all
Results
There were 170 women who collectively underwent 233 IVF/ICSI cycles with complete anthropometric and clinical data available for analyses. Women were primarily Caucasian (86%), had never smoked (72%), and had a mean (SD) age of 35.4 (3.9) years. The mean (SD) BMI at study enrollment was 24.5 (4.7) kg/m2, with 35% of women being overweight (BMI 25–29.9 kg/m2) or obese (BMI ≥30 kg/m2). The average time between study enrollment and the anthropometric evaluation preceding their first ART cycle was
Discussion
We examined the associations of BMI and short-term weight change with embryologic and clinical outcomes in a contemporary cohort of women undergoing infertility treatment with ART. As expected, BMI was associated with reduced peak E2 levels and live birth rates. Losing weight before initiation of ART was related to higher yield of MII oocytes, particularly among women who were overweight or obese at baseline. Short-term weight change, however, was not related to clinical outcomes among women
Acknowledgments
The authors thank the study participants and research nurses Jennifer Ford, B.S.N., R.N., and Myra Keller, B.S.N., R.N., for their contributions.
References (40)
- et al.
Female obesity impairs in vitro fertilization outcome without affecting embryo quality
Fertil Steril
(2010) - et al.
The influence of body mass index on in vitro fertilization outcome
Int J Gynaecol Obstet
(2009) - et al.
Effect of increased body mass index on oocyte and embryo quality in IVF patients
Reprod Biomed Online
(2007) - et al.
Impact of isolated obesity on ICSI outcome
Reprod Biomed Online
(2008) - et al.
Extremes of body mass index reduce in vitro fertilization pregnancy rates
Fertil Steril
(2003) - et al.
Body mass index is inversely related to intrafollicular HCG concentrations, embryo quality and IVF outcome
Reprod Biomed Online
(2001) - et al.
Obesity does not adversely affect results in patients who are undergoing in vitro fertilization and embryo transfer
Eur J Obst Gynecol Reprod Biol
(2006) - et al.
Failure of body mass index or body weight to influence markedly the response to ovarian hyperstimulation in normal cycling women
Fertil Steril
(1990) - et al.
Impact of body mass index on IVF and ICSI outcome: a retrospective study
Reprod Biomed Online
(2008) - et al.
Polycystic ovary syndrome, body mass index and outcomes of assisted reproductive technologies
Reprod Biomed Online
(2009)
Physical activity, body mass index, and ovulatory disorder infertility
Epidemiology
Diet and lifestyle in the prevention of ovulatory disorder infertility
Obstet Gynecol
Prevalence and trends in obesity among US adults, 1999-2008
JAMA
Overweight and obesity in the United States: prevalence and trends, 1960-1994
Int J Obes Relat Metab Disord
Female obesity adversely affects assisted reproductive technology (ART) pregnancy and live birth rates
Hum Reprod
Obesity and in vitro fertilization: negative influences on outcome
J Reprod Med
Should access to fertility treatment be determined by female body mass index?
Hum Reprod
The direct health services costs of providing assisted reproduction services in overweight or obese women: a retrospective cross-sectional analysis
Hum Reprod
Overweight and obesity in infertility: cost and consequences
Hum Reprod Update
Should obese women with polycystic ovary syndrome receive treatment for infertility?
BMJ
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J.E.C. has nothing to disclose. S.E. has nothing to disclose. D.S.C. has nothing to disclose. D.L.W. has nothing to disclose. T.L.T. has nothing to disclose. J.C.P. has nothing to disclose. R.H. has nothing to disclose.