Immunity
Volume 32, Issue 1, 29 January 2010, Pages 79-90
ArticleInterleukin-2 and Inflammation Induce Distinct Transcriptional Programs that Promote the Differentiation of Effector Cytolytic T Cells
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Highlights
► Strong, sustained IL-2 signals promote effector and repress memory CTL development ► IL-2Rα is required for effective effector CTL differentiation during viral infection ► IL-2 induces eomesodermin and perforin gene transcription by recruiting RNA Pol II ► Complex interplay between inflammation and IL-2 for gene regulation in CD8+ T cells
MOLIMMUNO
CELLIMMUNO
Cited by (0)
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Present Address: Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, Miami, FL 33136, USA
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These authors contributed equally to this work
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