Immunity
Volume 33, Issue 1, 23 July 2010, Pages 60-70
ArticleK33-Linked Polyubiquitination of T Cell Receptor-ζ Regulates Proteolysis-Independent T Cell Signaling
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Graphical Abstract
Highlights
► Loss of Itch and Cbl-b results in excessive T cell activation and autoimmunity ► Itch and Cbl-b target TCR-ζ for K33-linked ubiquitination without its degradation ► K33 ubiquitination inhibits TCR-ζ phosphorylation and Zap-70 interaction ► Ubiquitination conjugation occurs at the juxtamembrane lysine 54 of TCR-ζ
CELLIMMUNO
MOLIMMUNO
Cited by (0)
- 3
Present address: School of Medicine, Inha University, Incheon 400-711, Korea
- 4
Present address: Millipore Corporation, Temecula, CA 92590, USA
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These authors contributed equally to this paper
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