Immunity
Volume 34, Issue 3, 25 March 2011, Pages 375-384
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Article
Selective Utilization of Toll-like Receptor and MyD88 Signaling in B Cells for Enhancement of the Antiviral Germinal Center Response

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Summary

The contribution of Toll-like receptor (TLR) signaling to T cell-dependent (TD) antibody responses was assessed by using mice lacking the TLR signaling adaptor MyD88 in individual cell types. When a soluble TLR9 ligand was used as adjuvant for a protein antigen, MyD88 was required in dendritic cells but not in B cells to enhance the TD antibody response, regardless of the inherent immunogenicity of the antigen. In contrast, a TLR9 ligand contained within a virus-like particle substantially augmented the TD germinal center IgG antibody response, and this augmentation required B cell MyD88. The ability of B cells to discriminate between antigens based on the physical form of a TLR ligand probably reflects an adaptation to facilitate strong antiviral antibody responses.

Highlights

► Virus particles engage B cell TLRs to promote the germinal center IgG response ► Dendritic cell TLRs can promote antibody responses to soluble protein antigens

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Present address: Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences. Beijing 100101, China