Continuing medical educationThe group of epidermal nevus syndromes: Part I. Well defined phenotypes
Section snippets
Well defined epidermal nevus syndromes characterized by organoid nevi
These ENSs are specified by the presence of epithelial nevi showing hyperplasia or structural changes of sebaceous glands or hair follicles (Fig 1).
Epidermal nevus syndromes characterized by keratinocytic nevi
These syndromes are defined by the presence of nonorganoid EN, showing differentiation exclusively to keratinocytes (Fig 1).
Synopsis of well defined epidermal nevus syndromes
Table VIII summarizes the distinguishing features of nine well defined ENSs. The molecular basis of three syndromes characterized by keratinocytic nevi has already been identified, whereas the origin of the ENSs specified by organoid nevi is so far unknown.
In my view, a biopsy specimen is not generally needed, but in cases of doubt this measure may be helpful to identify a sebaceous, Becker, or CHILD nevus. In cases of noninflammatory keratinocytic nevi, histopathologic examination may
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