Cardiovascular Genomic Medicine
Gene Expression Analysis of Cardiovascular Diseases: Novel Insights Into Biology and Clinical Applications

https://doi.org/10.1016/j.jacc.2006.02.070Get rights and content
Under an Elsevier user license
open archive

Although the contribution of genetics to complex cardiovascular diseases such as atherosclerosis has been accepted for quite some time, full and detailed knowledge of the individual causative genes has been elusive. With the advent of genomic technologies and methods, the necessary tools are now available to begin pinpointing the genes that contribute to disease susceptibility and progression. One approach being applied extensively in candidate gene discovery is gene expression analysis of human and animal tissues using microarrays. The genes identified by these genomic studies provide valuable insight into disease biology and represent the initial steps toward the development of diagnostic tests and therapeutic strategies that will substantially improve human health. This paper highlights the progress that has been made in using gene expression analysis cardiovascular genomic research and the potential for applying these findings in clinical medicine.

Abbreviations and Acronyms

CARGO
Cardiac Allograft Rejection Gene Expression Observational study
DNA
deoxyribonucleic acid
ICM
ischemic cardiomyopathy
LVAD
left ventricular assist device
mRNA
messenger ribonucleic acid
NF
nonfailing (myocardial samples)
NICM
nonischemic cardiomyopathy
PMBC
peripheral blood mononuclear cell
QTL
quantitative trait locus
SNP
single nucleotide polymorphism

Cited by (0)

Joshua Hare, MD, served as guest editor for this article.